In elderly patients, what factor may cause adverse events related to medication use?

Elderly patients often experience adverse events related to medication use due to increased sensitivity to medications, particularly central nervous system agents. This increased sensitivity is attributed to various physiological changes that occur with aging, such as alterations in metabolism, distribution, and excretion of drugs. For example, elderly individuals may have altered receptor sensitivity, changes in neurotransmitter levels, or compromised homeostatic mechanisms that make them more vulnerable to the effects of certain drugs.

As a result, even standard doses of medications can lead to a higher incidence of side effects, complications, or toxicity in this population. Recognizing this heightened sensitivity is crucial in the practice of medication therapy management to ensure appropriate prescribing and monitoring, as well as to minimize the risk of adverse events, thereby improving patient outcomes.

Understanding this concept emphasizes the importance of individualized therapy and careful consideration of medication choices, especially for elderly patients who may have multiple comorbidities and polypharmacy situations.